Jackfruit (Artocarpus heterophyllus Lamk) Leaf as a Natural Sun Stick Protector Through the Inhibition of the MMP-1 Receptor

Sunlight contains ultraviolet radiation, which can cause the formation of free radicals. One plants that has potential to be used as sunscreen is jackfruit (Artocarpus heterophyllus Lamk). This research aimed determine sun stick leaf extract a UV-Protector exposed UV-B radiation. study two methods, namely in vitro and vivo. In vitromethod was carried out using spectro-photometric method analyze value Sun Protection Factor vivo one Balb/c strain male white mice, were divided into three treatment groups. From results, it reported SPF at concentration 2,500 ppm 36.62; 5,000 38.66; 7,500 38.85, 10,000ppm 38.33, indicating average each belongs ultraprotection category. The showed sticks gave lowest levels MMP-1; results 3.713 ng/ml mouse blood serum, lower when compared other brands with MMP-1 3.86 ng/ml. highest level shown by on sun-stick basis, 4.737 above indicate inhibit expression MMP-1, reflecting its ability UV protector because active compound components. inhibits expressionby inhibiting mitogenic-activated protein kinase (MAPK) pathway.&nbsp